What is it about?
Our research describe a new electrophysiological procedure for glaucoma diagnosis: through the evaluation of the phase variability of the 2nd harmonic assessed by steady-state perg, repeated five consecutive times, we noted it can detect RGCs dysfunction in early glaucoma. We showed that the individual intrinsic within-trial variability of the PERG signal in test-retest of the same eye (i. e., five consecutive stimulations without pause, procedure that we called RE-PERG) of early glaucoma patients was greater than the physiological one present in healthy individuals.
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Why is it important?
Increased intrinsic variability of the signal may be a biological marker of preapoptotic dysfunction of retinal neurons, and perhaps in the future of all the nerve cells. We have called this behavior of electroretinography signal as a neural-rhythm, and may be useful to identify other neurodegenerative diseases like Alzheimer's. On the other hand, patological behaviour of neural rythm may be a new biological marker of neural cell dysfunction before dies.
Perspectives
In the future all potential evoked, retinal or cortical or acoustic will be studied with consecutives stimulations that, through evaluation of the phase variability, could show the neural rythm in various neurological diseases. This will could give you new informations about the physiopatology of neurodegenerative diseases.
Alberto Mavilio
Azienda Sanitaria Locale Brindisi
Read the Original
This page is a summary of: RE-PERG, a new procedure for electrophysiologic diagnosis of glaucoma that may improve PERG specificity, Clinical Ophthalmology, January 2017, Dove Medical Press,
DOI: 10.2147/opth.s122706.
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