Construction of injectable, pH sensitive, antibacterial, mineralized amino acid yolk-shell microspheres for potential minimally invasive treatment of bone infection

Zhenhua Chen, Mengen Zhao, Jie Zhang, Kang Zhou, Xiuli Ren, Xifan Mei
  • International Journal of Nanomedicine, June 2018, Dove Medical Press
  • DOI: 10.2147/ijn.s157463

Mineralized Amino Acid into Yolk-shell Microspheres Used for Treatment of Bone Infection

What is it about?

Amino acid (L-lysine (Lys)) was mineralized into Yolk-shellyolk-shell structured CaCO3 microspheres. The as prepared Lys encapsulated CaCO3 microspheres (Lys@CaCO3 MSs) were used as micro-drug to improve acidic environment of osteomyelitis caused by bacterial infection and promote osteoblast proliferation under oxidative stress.

Why is it important?

Treatment of infection within bone is difficult, and conventional surgical treatment brings great pain to the patients physically and mentally, . it It is very urgent that to develop injectable nano and/or micro medicine for minimally invasive treatment of osteomyelitis.

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