What is it about?

This study investigated the carriage of AmpC gene among multidrug-resistant Salmonella spp. from Lagos, Nigeria. The study identified emergence of AmpC b-lactamase–producing Salmonella isolates in our environmentwas recorded for the first time, raising concern on increased antibiotic resistance among strains of Salmonella serovars in Lagos.

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Why is it important?

This study revealed the occurrence of plasmid-mediated AmpC β-lactamases producing MDR Salmonella isolates in our environment for the first time. It also showed the coexistence of ESBL and AmpC β-lactamases (fox gene) in some strains of Salmonella isolates. A need to screen the ESBL potential of MDR Salmonella isolates for plasmid-mediated AmpC β-lactamases, along with performing antibiogram is advocated before making therapeutic decisions in patient management in our hospitals. This is essential to prevent treatment failure and stem mortality.


. Therefore, in view of the potential impact of β-lactamase–producing organisms on the clinical outcomes among infected patients in our environment, this study was undertaken to investigate the occurrence of ESBLs and AmpC enzymes among multidrug-resistant Salmonella isolates.

Kabiru Olusegun Akinyemi

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This page is a summary of: Occurrence of extended-spectrum and AmpC β-lactamases in multiple drug resistant Salmonella isolates from clinical samples in Lagos, Nigeria, Infection and Drug Resistance, January 2017, Dove Medical Press, DOI: 10.2147/idr.s123646.
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