What is it about?

When insulin resistance is the primary initiator of pathologic processes, reactive hyperinsulinism and estrogen deficiency are the characteristic laboratory findings. When resistance of estrogen receptors is the primary disorder, reactive hyperestrogenism is the predominant hormonal alteration, while patients show clinical signs of weak estrogen signal. Estrogen deficiency and androgen excess without counteractions leads to further breakdown of cellular mechanisms, while estrogen excess is a beneficial effort for health improvement,

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Why is it important?

Since cellular estrogen surveillance has crucial role in mammary health, either the inhibition of aromatase enzyme activity or estrogen receptor blockage jeopardizes the structural and functional integrity of female breast.


The higher the resistance of estrogen receptors, the higher is the promising dose of estrogen for prevention and treatment of breast cancer.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

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This page is a summary of: Diverse pathomechanisms leading to the breakdown of cellular estrogen surveillance and breast cancer development: new therapeutic strategies, Drug Design Development and Therapy, September 2014, Dove Medical Press,
DOI: 10.2147/dddt.s70570.
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