Cadmium is an important citrullinating agent
What is it about?
Cadmium exposure is associated with a number of diseases. Cigarette smoking is the most important environmental source of cadmium. Therefore smoking related diseases such as COPD and rheumatoid arthritis (RA) may be triggered by cadmium exposure. Citrullination an irreversible post-translational modification that is observed in RA and COPD. This paper examines if cadmium oxide generated under the conditions that exist in the burning cigarette citrullinates proteins within lung epithelial cells
Why is it important?
This research is of importance as it may explain the strong epidemiological link that exists between RA and COPD and explain why COPD can progress following smoking cessation as cadmium has a half life of approximately 2 decades.
The following have contributed to this page: Navin Kumar Verma, luisana di cristo, and David Hutchinson