What is it about?
S100A16 belongs to the Ca2+ binding protein. We have shown that it can promote the chemoresistance of bladder cancer based on chemoresistant cell line. This may be related to its anti-apoptosis effect.
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Why is it important?
Our findings show that S100A16 can promote the chemoresistance of nonmuscle invasive bladder cancer through anti-apoptosis pathway, thus providing a new strategy to prevent or reverse the bladder cancer chemoresistance.
Perspectives
Proteomics is a great tool to find significant markers. However, it needs to be verified using experimental methods. The relationship between S100A16 and chemoresistance was discovered occasionally. It's exited for me to find and prove it, though the mechanisms were not studied deeply. I hope you find this article thought-provoking.
Chanjuan Wang
Peking University Third Hospital
Read the Original
This page is a summary of: S100A16 regulated by Snail promotes the chemoresistance of nonmuscle invasive bladder cancer through the AKT/Bcl-2 pathway, Cancer Management and Research, March 2019, Dove Medical Press,
DOI: 10.2147/cmar.s196450.
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