What is it about?

By using an iTRAQ-based proteomics technique, we investigated a series of serum after radical resection during the follow-up of 4 HCC patients and identified the high serum level of PGK1 was closely associated with HCC early recurrence and poor prognosis.

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Why is it important?

There is still lacking of highly sensitive and specific biomarkers for the prediction of hepatocellular carcinoma (HCC) early recurrence, which has hindered further improvement of the clinical outcomes. We found that PGK1 might be an independent factor for the recurrence of HCC. And the PGK1 could be complementary with AFP to further improve the sensitivity and specificity in prognostic prediction of HCC relapse.


Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to the serum proteomic technology contacting me and ultimately to a greater involvement in the biomark screening for other diseases.

Hongzhi Liu
Fujian Medical University

Read the Original

This page is a summary of: The serum proteomics tracking of hepatocellular carcinoma early recurrence following radical resection, Cancer Management and Research, April 2019, Dove Medical Press,
DOI: 10.2147/cmar.s190561.
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