What is it about?
Dexamethasone inhibits tumor proliferation through glucose metabolism and immunity
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Why is it important?
DEX can inhibit tumor cells in vitro and in vivo. The mechanism is to inhibit the activation of mTOR signaling pathway by inhibiting the expression of c-Myc, further affecting the expression of key enzymes involved in glucose metabolism, especially PCK2.In addition, DEX has an inhibitory effect on the immune system, which may be the reason why DEX still has anti-tumor effect in normal mice
Perspectives
Previously, DEX has been shown to inhibit the function of immune system; however, DEX is often used to treat side reactions, such as nausea and vomiting caused by chemotherapy in clinics. Therefore, it is necessary to study the role of DEX in the treatment of cancer
Yuantao Wu
Soochow University
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This page is a summary of: Dexamethasone inhibits the proliferation of tumor cells, Cancer Management and Research, February 2019, Dove Medical Press,
DOI: 10.2147/cmar.s187659.
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