What is it about?
The difference of minor allele frequency of ABCG2 variants are reflected to frequency of ABCG2 dysfunction.
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Why is it important?
Japanese have more dysfunctional ABCG2 compared with Caucasian and African American, but still much individuals have gout risk.
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This page is a summary of: Ethnic Differences in ATP-binding Cassette Transporter, Sub-family G, Member 2 (ABCG2/BCRP): Genotype Combinations and Estimated Functions, Drug Metabolism and Pharmacokinetics, January 2014, Japanese Society for the Study of Xenobiotics,
DOI: 10.2133/dmpk.dmpk-14-sc-041.
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