Nonsteroidal Anti-Inflammatory Drugs and Bone-Healing

  • A Systematic Review of Research Quality
  • Alejandro Marquez-Lara, Ian D. Hutchinson, Fiesky Nuñez Jr., Thomas L. Smith, Anna N. Miller
  • JBJS Reviews, March 2016, The Journal of Bone and Joint Surgery, Inc.
  • DOI: 10.2106/jbjs.rvw.o.00055

What is it about?

Systematic review of available clinical evidence addressing the effects of NSAIDs on bone healing. Provides insight into the disconnect between basic science and clinical literature as well as the quality of published literature on this controversial topic.


Dr Alejandro Marquez-Lara
Wake Forest School of Medicine

There is no clear evidence to support that NSAIDs inhibit bone healing in the clinical setting. Therefore, it may not be appropriate to withhold NSAIDs and their pain-relieving benefits from patients undergoing orthopaedic procedures. Unfortunately, there is also no good evidence confirming the safety of NSAIDs with regards to bone healing, which is likely that any detrimental effect is dose and time dependent. Orthopaedic surgeons attempting to better characterize the effects of NSAIDs on bone healing are encouraged to read this review to improve the quality of ongoing and future clinical studies.

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The following have contributed to this page: Dr Alejandro Marquez-Lara