What is it about?
Using a combination gas consisting 10% CO2 and 90% O2, our team successfully stopped hiccups in 35 consecutive cases (26 patients) with persistent hiccups. The number of cases has been increasing (60 cases (33 patients), Oct. 1, 2020). We found that hiccups stop when the partial pressure of CO2 in blood reaches around 60 mmHg.
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Why is it important?
We can always stop hiccups, but we cannot get rid of the “ignition” of hiccups yet. The starting or restarting mechanism is still mystery. The greater our knowledge about hiccups increases, the greater our ignorance about them unfolds. So, I need your help. But this paper gives you a great hint to break their enigma.
Perspectives
Using our method, we can instantly stop hiccups. Researchers may be able to reveal the mechanisms to restart hiccups in the brain using MRI, PET/CT, and so on, if they can employ patients with persistent hiccups as volunteers. In addition, the role of the diaphragm is the key to understand the nature of hiccups; it is likely that hiccups should be an abnormal reflex of swallowing.
Dr. Toshiro Obuchi
Read the Original
This page is a summary of: Preliminary experimental outcomes of induced hypercapnia in treatment of obstinate singultus, Journal of Thoracic Disease, August 2020, AME Publishing Company,
DOI: 10.21037/jtd-20-1049.
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