What is it about?
The activities of maternal thyroid hormones (THs) can induce important actions on the neural development, synaptogenesis, and normal brain development during the perinatal period. The developing autism due to the maternal hypothyroidism may be disrupted the activities of D2 and D3, the levels of T4 and T3, and the gene and thyroid receptors (TRs) expression resulting in a region specific T3 deficiency in the neonatal brain. These maternal disorders may impair the social, learning, and economic interactions for the neonates. Future studies are warranted to explore the developmental and molecular interactions of maternal thyroid dysfunction (thyroid stimulating hormone (TSH), T4 and T3) and autism development. Other studies are required to determine the activities of Ds and gene expression in ASD.
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Why is it important?
These maternal disorders may impair the social, learning, and economic interactions for the neonates.
Perspectives
Future studies are warranted to explore the developmental and molecular interactions of maternal thyroid dysfunction (thyroid stimulating hormone (TSH), T4 and T3) and autism development. Other studies are required to determine the activities of Ds and gene expression in ASD.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Is there a Connection between Maternal Hypothyroidism and Developing Autism Spectrum Disorders?, ARC Journal of Neuroscience, January 2018, ARC Publications Pvt Ltd.,
DOI: 10.20431/2456-057x.0301002.
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