What is it about?
The direct associations between NRG1 and integrin αvβ3 were significant for the activation of the ErbB receptor-tyrosine kinases resulting in downstream signaling activation of Akt and ERK1/2
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Why is it important?
Thyroxine (T4) has the ability to increase EGF and TGF-α-induced MAPK activation in HeLa cells that lacked thyroid receptors (TRs). However, NRGs are implicated in several diseases such as schizophrenia, cancer and cardiovascular disorders
Perspectives
understanding the role of THs in this crosstalk may facilitate the development of new tools for therapeutic intervention, and in this context the nanotetrac formulation appears to be very promising. Additional studies are wanted to identify the crosstalk between THs and growth factors to prove the efficacy of new pharmacological drugs.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Interactions between Thyroid and Growth Factors during Development, ARC Journal of Diabetes and Endocrinology, January 2018, ARC Publications Pvt Ltd.,
DOI: 10.20431/2455-5983.0401001.
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