What is it about?
Any disorders in the communications between the hypothalamus-pituitary-thyroid axis (HPTA) and the hypothalamic-pituitary-adrenal axis (HPAA) during the gestation may cause a depression in both mothers and fetuses/neonates. The endocrine anomalies may increase the risk of morbidity and several developmental disorders. Dysfunction in the HPTA and HPAA can cause the major depressive disorders. Thus, additional studies are necessary to understand the potential associations between the fetal/perinatal adrenal-thyroid disorders and depression. Future examinations are wanted to discover whether the effect of maternal thyroid hormone replacement therapy on the developmental thyroid-adrenal axis play a role in modifying the signaling pathways to enhance the atypical, melancholic or severe depression during the perinatal period.
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Why is it important?
Any disorders in the communications between the hypothalamus-pituitary-thyroid axis (HPTA) and the hypothalamic-pituitary-adrenal axis (HPAA) during the gestation may cause a depression in both mothers and fetuses/neonates.
Perspectives
Additional studies are necessary to understand the potential associations between the fetal/perinatal adrenal-thyroid disorders and depression. Future examinations are wanted to discover whether the effect of maternal thyroid hormone replacement therapy on the developmental thyroid-adrenal axis play a role in modifying the signaling pathways to enhance the atypical, melancholic or severe depression during the perinatal period.
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Maternal Thyroid-Adrenal Dysfunction and Fetal-Neonatal Depression, ARC Journal of Animal and Veterinary Sciences, January 2018, ARC Publications Pvt Ltd.,
DOI: 10.20431/2455-2518.0402007.
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