What is it about?
To distinguish between effects that are strictly dose-dependent and those that depend on dose and exposure time. Dose-dependent toxicity points to reversible receptor binding, for which thresholds can be defined. Dose-and time-dependent toxicity points to slowly reversible or even irreversible receptor binding which leads to cumulative toxicity with no apparent threshold
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Why is it important?
Application of the strategy would shift product development to dose-dependent toxicity and could make a myriad of animal studies superfluous, and make a contribution to implementation of the 3R principles, in combination with in vitro toxicity studies, and a reduction of the costs of product development
Perspectives
Product development could be simplified with shorter lead times and much lower use of laboratory animals
Dr Henk A. Tennekes
Experimental Toxicology Services (ETS) Nederland BV
Read the Original
This page is a summary of: The Importance of Dose-Time-Response Relationships for Hazard Identification and Limitation of Animal Experiments, Open Access Journal of Toxicology, August 2017, Juniper Publishers,
DOI: 10.19080/oajt.2017.01.555572.
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