Possible renoprotection of cilnidipine

What is it about?

The present study is designed to determine the effect of cilnidipine on creatinine clearance, thiobarbituric acid reactive substance, as an index of lipid peroxidation. Additionally, the level of superoxide dismutase enzyme in erythrocyte lysates and kidney catalase enzyme activitiy will be measured. Thirty-six albino rats are divided into 3 separate groups: rats of group 1 are control group, rats of group 2 are administered by deoxycorticosterone acetate (DOCA) salt sc twice/week + 1% NaCl for 2 weeks to be rendered hypertensive) and group 3 will receive 9 mg/kg cilnidipine for 3 weeks intragastrically after induction of hypertension by DOCA-salt as group 2. Results: DOCA-injected albino rats show marked reduction in creatinine clearance. Treatment with cilnidipine improves creatinine clearance compared to the non-treated hypertensive group 2. Additionally, it reduces thiobarbituric acid reactive substance, as an index of lipid peroxidation, with a significant increase in superoxide dismutase enzyme in erythrocyte lysates and kidney catalase enzyme activities. Conclusion: This study points to the possible beneficial renal protective effects of cilnidipine in hypertensive albino rats injected with DOCA for 2 weeks.

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Why is it important?

The tested dihydropyridine CCB cilnidipine could protect albino rats against the impairment of kidney function evoked by hypertension induced by DOCA salt injection for 2 weeks, and this may contribute to the beneficial effect against end-organ damage and oxidative stress reported in clinical trials. Further investigations on cilnidipine are needed to discover their beneficial role in protection or management of renal diseases.