What is it about?

The purpose of this study was to investigate whether smeathxanthone A isolated from G arcinia smeathmanii improves incisional wound healing in diabetic mice. Male albino alloxan-induced diabetic mice ( n = 20) were divided into five groups: normal control, diabetic control, 2.5 mg/kg glibenclamide given orally, 0.05 and 0.1 mg/kg smeathxanthone A given subcutaneously. Animals were euthanized on postoperative day 10 after wounding; body weight, blood glucose, breaking strength, and histologic examination were reviewed. Smeathxanthone A significantly increased skin tensile strength (24% higher than diabetic control group when given at 0.1 mg/kg), stimulated hair growth, and reduced signs of inflammation in the scar sections. Smeathxanthone A also reduced blood glucose levels in diabetic mice (45% higher than diabetic control group when given at 0.1 mg/kg).

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Why is it important?

The present study demonstrates that administration of smeathxanthone A after laparotomy expedites wound healing in mice. We suggest that it could confer benefits to tissue healing by significantly enhancing tissue collagen deposition and controlling blood glucose levels.

Perspectives

Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.

Professor Alain Meli Lannang

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This page is a summary of: Antidiabetic and Wound Healing Effects of Smeathxanthone A, Recent Advances in Biology and Medicine, January 2016, HATASO Enterprises LLC (Aston Journals), DOI: 10.18639/rabm.2016.02.271146.
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