What is it about?
This study looked at blood-clotting conditions, known as thrombophilia, among Sudanese women and examined whether these conditions were linked to adverse pregnancy outcomes, especially pregnancy loss. Thrombophilia can make the blood more likely to clot, which may affect blood flow to the placenta and contribute to complications during pregnancy. In this cross-sectional study, we assessed Sudanese women for selected thrombophilia markers, including protein S deficiency, protein C deficiency, and Factor V Leiden mutation. We found that thrombophilia markers were relatively common in the study group, with protein S deficiency being the most frequent marker. The findings suggested that low protein S levels were particularly associated with late pregnancy loss, while some other markers showed weaker or less clear associations. The study adds local evidence from Sudan, where data on thrombophilia and pregnancy outcomes remain limited. It highlights the need for careful clinical assessment of women with recurrent or unexplained pregnancy loss, especially in settings where access to advanced testing may be limited.
Featured Image
Photo by Suhyeon Choi on Unsplash
Why is it important?
Pregnancy loss has major emotional, clinical, and public health consequences, but the underlying causes are not always identified. In Sudan and similar low-resource settings, local evidence on thrombophilia and adverse pregnancy outcomes is still limited. This study is important because it provides Sudanese data on the frequency of selected thrombophilia markers and their relationship with pregnancy loss. The main practical message is that protein S deficiency may deserve particular attention when evaluating women with adverse pregnancy outcomes, especially late pregnancy loss. The findings do not mean that all women should be screened routinely, but they support more informed, risk-based assessment and encourage further research using larger, well-designed studies. By improving local evidence, this work may help clinicians, researchers, and policy makers consider more context-appropriate approaches to investigating pregnancy loss.
Perspectives
As researchers working in a setting where advanced diagnostic testing is not always easily accessible, we wanted this study to contribute practical local evidence rather than rely only on data from other populations. Pregnancy loss is often clinically complex and emotionally distressing for families, and identifying possible contributing factors is important for better counseling and care. Our findings suggest that thrombophilia, particularly protein S deficiency, may be relevant in some Sudanese women with adverse pregnancy outcomes. We hope this work encourages further collaborative research, stronger local datasets, and more careful risk-based evaluation of women with unexplained or recurrent pregnancy loss.
Faris Abdon
Orotta School of Medicine and Dentistry
Read the Original
This page is a summary of: Prevalence and Clinical Significance of Thrombophilia in Adverse Pregnancy Outcomes Among Sudanese Women: A Cross-sectional Study, Sudan Journal of Medical Sciences, June 2026, Knowledge E,
DOI: 10.18502/sjms.v21i2.19829.
You can read the full text:
Contributors
The following have contributed to this page
