What is it about?

Herpes virus infection represents the first cause of corneal blindness in developing countries. Understanding the pathologic and reparative changes occurring in the cornea during and after HSV infection is crucial. We conducted a systematic in-vivo spectral-domain optical coherence tomography (AS-OCT) corneal analysis of the microstructural changes occurring in active and inactive herpetic stromal keratitis and compared non-necrotizing with necrotizing variants. This analysis is the first in its kind, bringing insights into the corneal inflammatory and reparative response to the immune-mediated and viral cytopathic effect of herpes virus type-1 in the cornea of susceptible individuals.

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Why is it important?

This in-vivo analysis is fundamental to understand better the microstructural pathologic changes induced by the herpes virus type 1 direct effect during infection and the adaptive immune-mediated response against it with their consequences in the corneal clarity.


The use and advantages of the cornea's ocular coherence tomography imaging technology have become an everyday practice clinical tool for pathologic analysis, diagnosis, and therapeutic monitoring of many different infectious, degenerative, and inflammatory corneal disorders.

Dr. Alejandro Rodriguez-Garcia
Instituto Tecnologico y de Estudios Superiores de Monterrey

Read the Original

This page is a summary of: In Vivo Corneal Microstructural Changes in Herpetic Stromal Keratitis: A Spectral-Domain Optical Coherence Tomography Analysis, Journal of Ophthalmic and Vision Research, July 2020, Knowledge E, DOI: 10.18502/jovr.v15i3.7446.
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