What is it about?
Sound speed (SS) correlates with the stiffness of the tissues. We observed orthopedic diseases by plotting SS values of each area. Each organ component shows different SS values to make characteristic images such as osteoporosis, woven and lamellar bones, fracture callus, intramembranous and cartilaginous bone formation, and neoplastic bone diseases.
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Why is it important?
Scanning acoustic microscope needs only 10-um unstained slides and can simultaneously compare mechanical stiffness and histology. Speed-of-sound images provide informative mechanical alterations of bone, cartilage, and connective tissues to assess the status and diagnose a disorder.
Perspectives
Ultrasound microscopes can bring different information about the tissue from light microscopes by discriminating tissue stiffness and viscosity. Increasing and decreasing cross-linking and protein degradation have been detected by this method.
Dr Katsutoshi Miura
Hamamatsu University School of Medicine
Read the Original
This page is a summary of: Simultaneous Evaluation of Stiffness and Histology in Orthopedic Diseases Using Scanning Acoustic Microscope, Medical Research Archives, January 2023, Knowledge Enterprise Journals,
DOI: 10.18103/mra.v11i8.4302.
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