What is it about?
The endocannabinoid system is involved in various physiological pathways in the human body. A large number of endogenous cannabinoids have been acknowledged, and cannabinoid receptor type 1 (CB-1) and cannabinoid receptor type 2 (CB-2) have been categorized. The activation of the endocannabinoid system could regulate the activity in several neural pathways. The complex functions of this system have generated multiple new targets for pharmacotherapies.
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Why is it important?
Several research studies have concentrated on the cannabis and endocannabinoid system. However, these efforts have been generally unsuccessful. Although cannabinoids have therapeutic potential, their psychoactive properties have largely limited their usage in clinical practice.
Perspectives
An understanding of human cannabinoid pharmacokinetics is important for the enlargement and monitoring of new therapeutic medications. The extensive manifestation and multipurpose functions of the endocannabinoid system not only support its promising potential as a drug target for various diseases but also make the unwanted side effects almost unavoidable. The discovery of an endocannabinoid signaling system has released new opportunities for research into understanding the mechanisms of cannabis actions, the role of the endocannabinoid system in homeostasis, and the development of treatment approaches on the phytocannabinoids.
Professor Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University
Read the Original
This page is a summary of: Cannabis and Endocannabinoid System, Journal of Addiction Medicine and Therapeutic Science, January 2021, Peertechz.com,
DOI: 10.17352/2455-3484.000047.
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