Miscarriages as a result of immune conflict

What is it about?

The article is an overview of the role of innate immunity, particularly Toll-like receptors, in pathogenesis of early miscarriages. In this review we also mentioned our own data concerns increased expression of Toll-like receptor TLR3 (ligand - double stranded DNA of viruses) and decreased expression of TLR6 (ligand - bacterial lipopeptides) in endometrium of patients with early miscarriages.

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Why is it important?

As infection and inflammation is one of the leading factors of early miscarriages, especially recurrent, a review helps to determine the role of innate immunity in initialization and regulation of inflammation in endometrium as a factor, which can lead in most common pregnancy complication in first trimester - early miscarriage.