What is it about?
TNF receptor-1 (TNFR-1), which plays a role in the development of endothelial cell dysfunction and inflammation, is expressed in the glomerular and peritubular capillary endothelium of the kidneys. Studies previously showed that serum levels of soluble TNF receptor- 1 (sTNFR-1) are associated with kidney disease progression among persons with established kidney disease. In this study of a multiethnic population without cardiovascular disease at enrollment, elevated baseline sTNFR-1 concentrations were strongly associated with the development of a 40% decline in eGFR over a decade. This association persisted after adjustment for kidney disease– associated covariates and other inflammatory biomarkers, suggesting that a high concentration of sTNFR-1, independent of previously known risk factors for kidney disease progression, predicts kidney function decline in a multiethnic population with few comorbidities.
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Why is it important?
This is one of the first studies showing in a healthy multi-ethnic population that circulating soluble TNFR-1 concentrations are associated with the development of kidney function decline at 10 years of follow up.
Perspectives
This work encourages the study of sTNFR-1 as a potential screening test to identify persons at higher risk of subsequent kidney function decline. The study also provides evidence that the TNF alpha and TNFR-1 pathways may be involved in the development of kidney function decline.
Pavan Bhatraju
University of Washington System
Read the Original
This page is a summary of: Association of Soluble TNFR-1 Concentrations with Long-Term Decline in Kidney Function: The Multi-Ethnic Study of Atherosclerosis, Journal of the American Society of Nephrology, October 2018, American Society of Nephrology,
DOI: 10.1681/asn.2018070719.
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