Neutralizing Antibody–Mediated Response and Risk of BK Virus–Associated Nephropathy

Morgane Solis, Aurélie Velay, Raphaël Porcher, Pilar Domingo-Calap, Eric Soulier, Mélanie Joly, Mariam Meddeb, Wallys Kack-Kack, Bruno Moulin, Siamak Bahram, Françoise Stoll-Keller, Heidi Barth, Sophie Caillard, Samira Fafi-Kremer
  • Journal of the American Society of Nephrology, October 2017, American Society of Nephrology
  • DOI: 10.1681/asn.2017050532

Prevent BKV-associated nephropathy

What is it about?

BK virus-associated nephropathy is one of the major causes of graft dysfunction and loss in kidney transplantation.The role of the humoral immune response in control of BKV infection has been a long-standing puzzle. This paper examines the impact of BKV neutralizing antibody titers on BKV infection occurence in kidney transplant recipients.

Why is it important?

We have demonstrated for the first time that BKV neutralizing antibodies can protect against BKV infection. We identified a cutoff value that allows patient stratification into lower and higher BKV disease risk groups at the time of transplantation. This finding offers a useful tool for clinicians to improve kidney transplant management and pave the way for the development of new preventive or therapeutic strategies.

Perspectives

Samira Fafi-Kremer (Author)
Hopitaux Universitaires de Strasbourg

Doing this bedside-to-bench research has been a great pleasure thanks to our close collaboration with clinicians.

Read Publication

http://dx.doi.org/10.1681/asn.2017050532

The following have contributed to this page: Samira Fafi-Kremer