Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates

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Experience with plasma cell targeted therapies has already demonstrated advantages over historical approaches with IVIG-based regimens. Recent observations in primates, mice and humans are demonstrating mechanisms that can be exploited to further enhance these therapies. These studies are important because amongst alternatives to IVIG-based treatments, they are the most advanced alternative approaches for improving antihumoral therapies in transplantation.

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