What is it about?

This editorial highlights cutting edge issue in the development of plasma cell targeted therapies that have been gleaned from primate, murine and human studies. The complex, reflexive responses that occur following plasma cell targeted therapies are discussed in detail.

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Perspectives

Experience with plasma cell targeted therapies has already demonstrated advantages over historical approaches with IVIG-based regimens. Recent observations in primates, mice and humans are demonstrating mechanisms that can be exploited to further enhance these therapies. These studies are important because amongst alternatives to IVIG-based treatments, they are the most advanced alternative approaches for improving antihumoral therapies in transplantation.

Steve Woodle
University of Cincinnati

Read the Original

This page is a summary of: Targeting Plasma Cells with Proteasome Inhibitors: Principles from Primates, Journal of the American Society of Nephrology, June 2017, American Society of Nephrology,
DOI: 10.1681/asn.2017040443.
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