Prophylactic Phosphate Restriction: A Strategy to Mitigate AKI-Associated Complications

What is it about?

In this issue, Hamid and coworkers publish their investigation of the effects of dietary phosphate restriction on FGF23 metabolism, mineral homeostasis, and inflammation in mice with folic acid-induced acute kidney injury (FA-AKI)._x000D_ The study found that preemptive dietary phosphate restriction markedly diminished the early rise in plasma FGF23 and prevented the rise in plasma phosphate, PTH, and calcitriol in mice with FA-AKI. Furthermore, the study provided evidence for phosphate-sensitive osseus Fgf23 mRNA expression and revealed that phosphate restriction, while not affecting kidney dysfunction, mitigated calciprotein particles (CPP) formation, inflammation, acidosis, cardiac dysfunction, and mortality in mice with FA-AKI. These findings suggest that phosphate restriction may have a prophylactic potential in patients at risk for AKI._x000D_

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