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Cutaneous melanoma is the most aggressive skin cancer; it is highly metastatic and responds poorly to current therapies. The expression of platelet-derived growth factor receptors (PDGF-Rs) is reported to be reduced in metastatic melanoma compared with benign nevi or normal skin. Authors investigate autocrine effects of PDGF-Rα expression in human melanoma cells and show that PDGF-Rα overexpression markedly inhibits melanoma growth, both in vitro and in vivo.
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This page is a summary of: Platelet-Derived Growth Factor-Receptor α Strongly Inhibits Melanoma Growth In Vitro and In Vivo, Neoplasia, August 2009, Elsevier,
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