What is it about?

Evidence relating to the evolution and behavior of molecules, which confirms the ancient origin of the molecular structure. The involvement of insulin-like and related material in signalling biological pathway and modulator effects is also reported. The review studies relieves the evolutionary origins of these insulin or insulin-like substances, and moves on to compare findings of metazoan insulin, or insulin-like substances and vertebrate insulin with respect to molecular structure, biological and immunological activities, and the technical difficulties of defining the molecular structure with the insufficient amount of material usually available.

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Why is it important?

Data obtained in an attempt to clarify the phylogenetic origin of the substance and functionality. The occurrence of the molecule, its reactivity characteristics and aspects of insulin or insulin-like receptors in unicellular cells.

Perspectives

investigators focus on the possible evolutionary ancestors of the insulin superfamily, e.g, insulins, insulin-related peptides, and the insulin-like growth factor.

Dr. Jorge A. López

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This page is a summary of: Insulin or insulin-like studies on unicellular organisms: a review, Brazilian Archives of Biology and Technology, November 2004, FapUNIFESP (SciELO),
DOI: 10.1590/s1516-89132004000600017.
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