What is it about?
The advantage of using tissue-specific decellularized pancreas tissue (DP) scaffold when creating bioengineered constructs of the pancreas over biopolymer-based collagen-containing hydrogel (BCH) scaffolds was identified. BCH and tissue-specific DP scaffolds contribute not only to preserving the viability of isolated Langerhans islets, but also to prolonging their secretory capacity for 10 days, compared with ILs monoculture.
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Why is it important?
The creation of a biomedical cell product – a bioengineered construct of the pancreas – is hampered by problems associated with maintaining the viability of isolated Langerhans islets .
Perspectives
The final aim is the creation of a bioengineered construct of the human pancreas
Professor Victor I. Sevastianov
Research Center of Transplantology and Artificial Organs
Read the Original
This page is a summary of: Comparative analysis of the secretory capacity of islets of langerhans cultured with biopolymer-based collagen-containing hydrogel and tissue-specific matrix, Russian Journal of Transplantology and Artificial Organs, February 2020, V.I. Shimakov Federal Research Center of Transplantology and Artificial Organs,
DOI: 10.15825/1995-1191-2019-4-45-53.
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