Assembly Controlled by Shape

What is it about?

The main aim of the paper is to mimicking the natural objects (protein, virus, bacteria, living cells) by polymer microsctructure different by shape (spherical, cubical and tetrahedral) with same surface chemistry and investigate interparticle interaction and its arrangement driven by shape. The model of the assembly of the solid and hollow core-shell polymer microparticles in the buffer and on substrate proposed by Lisunova et al had been utilized for this study.

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Why is it important?

Such research is critically important to guide assembly of the bacteria encapsulated to biopolymer shell in aqueous buffer and on different surfaces. For instance, control the streptococcal cells (spherical in shape with polymer shell on top) assembly (chain-like structure) will allow to preclude the spreading the cells on the surface and reduce their mobility and as the result eliminate the infection appearance. Moreover, using the analogy of the control spherical microcapsules assembly to dimers will potentially allow to control the growth of the coccus to diplococcus. The grain-like assembly of the spherical coccus to staphylococcus could be explained based on the model of balance forces specifically the hydrophobic interaction between the coccus dominate over interaction with the substrate, and Columbic forces. Based on the model such staphylococcus are low mobile compare to streptococcus (coccus could be easily rearrange).

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