What is it about?
A fast, reliable method has been developed for the determination of cannabis metabolite (THC-COOH) in urine, using LC—MS/MS. It could be detected in 1.75min in LC-MS/MS. Comprehensive validation was performed. Even 1.41 ng/mL could be detected usin this method. HorRat was calculated to assess the inter-day and inter-analyst precision values. Successful results were obtained with the CEDIA positive real samples containing cannabis.
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Why is it important?
Cannabinoids are components of marijuana and its metabolite THC-COOH is excreted in the urine of the users. To detect if a suspected person has used cannabis, a fast, reliable, sensitive, simple method is needed fo4r routine analysis.
Perspectives
You can detect the mariuana metabolite in 2 minutes with a simple HPLC column without using UPLC after you extract the metabolite from urine in one step, using a simple Toxi-tube method. HorRat assessment for intermediate precisions was used exraordinarily in a forensic determination method.
Assoc. Prof. Dr. Beril ANILANMERT
Istanbul Üniversitesi-Cerrahpaşa
Read the Original
This page is a summary of: Fast confirmation for marijuana metabolite: THC-COOH, ultra-fast LC—MS/MS run time, and application to routine samples, Acta Chromatographica, June 2017, Akademiai Kiado,
DOI: 10.1556/1326.2017.29.2.09.
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