Panton–Valentine leukocidin gene of Staphylococcus aureus

What is it about?

Panton–Valentine leucocidin (pvl) gene is one of the important virulence factors in S. aureus. The product of pvl gene can cause opening of calcium channels, necrosis, and apoptosis of human leukocytes. Positive pvl strains of S. aureus have high virulence and are more accompanied by furuncle, skin abscesses, and infections with severe necrosis. Molecular typing of S. aureus is a useful tool to discriminate isolates during tracing source of infection and to strengthen infection control.

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Why is it important?

Since infection with the bacteria, S. aureus is very prevalent and toxin-producing bacteria create problems at the society level, so it is necessary to use proper diagnostic method, especially molecular methods to identify virulence factors as pvl gene.

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