What is it about?

We studied the degradation behavior of lacosamide. A total of 7 degradation products were analyzed and 4 degradation products under the oxidative conditions were detected and identified for the first time.

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Why is it important?

The results of this study suggest that lacosamide was unstable under the acidic, alkaline, and oxidative stress conditions, and should be stored in a tightly sealed container, protected from oxidizing agents. The plausible degradation pathway for formation of the degradation products was laid out.


Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also inspired my interest in impurity research.

Qiao Wang
Hebei Medical University

Read the Original

This page is a summary of: Identification of forced degradation products of lacosamide by LC-QqLIT-MS and LC-IT/TOF-MS, Acta Chromatographica, January 2019, Akademiai Kiado,
DOI: 10.1556/1326.2018.00279.
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