What is it about?
Morphological alterations of the neuronal organelles, concerning mainly microtubules, mitochondria, and Golgi apparatus affecting protein trafficking, have been described by histochemical techniques as well as in electron microscopy
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Why is it important?
It must be emphasized that mitochondrial alterations are particularly prominent in neurons, which show loss of dendritic spines, abbreviation of the dendritic arbors and synaptic alterations . In addition, many morphological alterations of AD, which are associated mostly with oxidative damage could be well linked to mitochondrial changes, since blockage of mitochondrial energy production shifts amyloid β-protein precursor metabolism to increased amyloidogenic activity
Perspectives
On the basis of the substantial role that mitochondrial pathology and mitochondrial genetic defects seems to play in the pathogenetic cascade of AD new strategies inducing protection to mitochondria by inhibition of mitochondrial β-oxidation , inhibition of ERK-DLP1 signaling and mitochondrial division, regulating calcium trafficking in the endoplasmic reticulum or via mitochondria and controlling mitochondrial calcium uptake by the administration of efficient antioxidant factors and natural antioxidants or using nanotechnology and supporting the neuroplasticity may be introduced in the treatment of early cases of Alzheimer’s disease.
Professor Stavros J Baloyannis or Balogiannis or Balojannis or Baloyiannis or Mpalogiannis
Aristotle University of Thessaloniki
Read the Original
This page is a summary of: Mitochondria and Alzheimer’s Disease, Journal of Neurology & Stroke, September 2014, MedCrave Group LLC,
DOI: 10.15406/jnsk.2014.01.00028.
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