What is it about?
Dendritic cells (DCs) are the unique antigen presenting cells (APCs) that can bridge innate and adaptive immune responses. Their roles in antigen uptake, processing, and presentation have been upgraded by various tools and techniques of biomedical research. The current article describes how the targeting of particulates by bone marrow-derived DCs (BMDCs) can be observed in vitro. This issue has been addressed by using flow cytometry and confocal microscopy. Elaborating these mechanisms will help understand the targeting activities of DCs in vitro and in vivo.
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Why is it important?
Antigen uptake; Micro particle; Particulate; Phagocytosis; Pinocytosis; Presentation; targeting
Perspectives
Dendritic cells (DCs) are the unique antigen presenting cells (APCs) that can bridge innate and adaptive immune responses. Their roles in antigen uptake, processing, and presentation have been upgraded by various tools and techniques of biomedical research. The current article describes how the targeting of particulates by bone marrow-derived DCs (BMDCs) can be observed in vitro. This issue has been addressed by using flow cytometry and confocal microscopy. Elaborating these mechanisms will help understand the targeting activities of DCs in vitro and in vivo.
Dr Tirth Raj Ghimire
Tribhuvan University
Read the Original
This page is a summary of: Visualizing Particulate Antigen Targeting to Dendritic Cells (DCs) In vitro, Journal of Nanomedicine Research, October 2014, MedCrave Group LLC,
DOI: 10.15406/jnmr.2014.01.00007.
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