What is it about?
We demonstrated here that IFNT affects diverse luteal functions in cows: it stimulated the expression of ISGs, IFN-associated genes, STAT1 phosphorylation, LECs survival and suppressed key luteolytic genes. These actions together may contribute to the maintenance of the bovine CL during early pregnancy.
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Why is it important?
We found out that IFNT acts via STAT1- IRF9-dependent and independent pathways and affects diverse luteal functions. Most interestingly, this study suggests the existence of an anti-luteolytic effect of IFNT in bovine CL, namely, inhibiting key PGF2a-induced luteolytic genes. The proliferative effect of IFNT may constitute an additional mechanism that promotes luteal cell survival, thus, extending the luteal life span during early pregnancy in cows.
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This page is a summary of: Interferon-tau promotes luteal endothelial cell survival and inhibits specific luteolytic genes in bovine corpus luteum, Reproduction, August 2017, Bioscientifica,
DOI: 10.1530/rep-17-0290.
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