What is it about?
During assisted reproduction for in vitro fertilization eggs and there surrounding cumulus granulosa cells are isolated. Cumulus cells are usually discarded while the oocytes that look mature are fertilized. The cumulus cells could provide information about egg quality and potential embryo quality. This review article summarizes work on cumulus cell RNA profiles to provide evidence of useful biomarkers for oocyte selection.
Featured Image
Why is it important?
In IVF procedures, many retrieved mature eggs look alike even when the majority will not give rise to a viable pregnancy. Having a non-invasive method (one that doesn't effect the egg or embryo) to determine which eggs are high quality will maximize pregnancy success. Analyzing cumulus cell biomarkers and relating it to oocyte quality is a non-invasive approach.
Perspectives
This approach could lead to a method of selecting the best eggs to fertilize for pregnancy even before they are fertilized.
Dr Holly A LaVoie
University of South Carolina
Examination of cumulus cell gene expression may be a non-invasive alternative to pre-genetic screening of embryos to determine the embryos capable of implantation.
Richard Kordus
University of South Carolina System
Read the Original
This page is a summary of: Granulosa cell biomarkers to predict pregnancy in ART: pieces to solve the puzzle, Reproduction, November 2016, Bioscientifica,
DOI: 10.1530/rep-16-0500.
You can read the full text:
Contributors
The following have contributed to this page
