Thyroid hormone receptor localization in target tissues

What is it about?

Trafficking of regulatory proteins to different compartments within a cell, including into and out of the cell nucleus where genetic information is stored and processed, is fundamental to the function of all living cells. In cancer and endocrine disorders this highly regulated traffic control may be disrupted. This review explores the signals regulating traffic control of thyroid hormone receptors, essential proteins which activate or repress gene expression in response to thyroid hormone, and play a pivotal role in human health, development, and metabolism.

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