Angiotensin II and insulin resistance

What is it about?

Angiotensin II (ANGII) is reportedly involved in the development of skeletal muscle insulin resistance. This study demonstrates for the first time that two pressor doses of ANGII induced differential metabolic responses at both the systemic and skeletal muscle levels.

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Why is it important?

The study demonstrates for the first time that ANGII at a commonly used dose (ANGII-100) and at a higher pressor dose (ANGII-500) differentially modulates metabolic features. In skeletal muscle, ANGII-100 induced skeletal muscle insulin resistance and impaired the insulin signaling pathway, while ANGII-500 normalized insulin-stimulated skeletal muscle glucose transport activity and other signaling molecules. At the whole body level, ANGII-100-treated rats were characterized by certain phenotypic manifestations that described non-obese insulin resistance syndrome, whereas ANGII-500 treated rats displayed diabetes-like features.

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