Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats

What is it about?

Chronic high fat diet (HFD) consumption leads to obese-insulin resistance. We show that Dipeptidyl peptidase-4 inhibitor shares similar efficacy as caloric restriction (switching from HFD to normal diet) for metabolic improvement, but exerts better cardioprotection than caloric restriction in HFD-induced obese-insulin resistant rats.

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