Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system

What is it about?

At present, the decrease in the birth rate index with a concomitant delayed maternity, it is been appearing as a major social problem. The access to professional studies of women has led her to economic stability, social independence and a delayed maternity. The delayed maternity after 30 years of age, not only provoke a decrease in fertility but also higher risk pregnancies due to associated diseases like hypertension, diabetes, genetic malformation due to damaged follicles and a decrease in successful in vitro fertilization procedures. This has stimulated multiples studies to understand the factors that regulate the follicular development and its relation with infertility, mainly at later ages, when a progressive loss of fertility occurred. We have characterized an animal model to study the ovarian aging process during the period of subfertility, to understand the mechanisms responsible of the accelerated loss of the follicular reserve that normally occurs since 37 years of age in the women. We have shown that sympathetic nervous systems together with kisspeptidergic system could be participate in the regulating of follicular development and ovarian function.

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