Incretins activate the corticoadrenal axis

What is it about?

Glucagon-Like Peptide-1 is a pleiotropic hormone having effects in the regulation of the hypothalamus-pituitary-adrenal axis. GLP-1 and its analogues increase the circulating levels of ACTH and glucocorticoids, and in addition activate the Sympathetic Nervous System. Although both processes might apparently counteract the insulinotropic activity of GLP-1, in fact, they contribute to positive metabolic effects as preventing post-prandial hypoglycemia or increasing lipolysis in the adipose tissue.

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Why is it important?

GLP-1 and GLP-1 receptor agonists regulate the insulin and glucagon secretions of pancreatic islets. However, they have more actions that are extensive and relevant in controlling metabolism. Several peripheral tissues as the liver, muscle or adipose tissues are targets for direct actions of GLP-1. In addition, GLP-1 participates in the central regulation of food intake, controls the neuroendocrine system and activates the HP-Adrenal axis and increases the Sympathetic Nervous System activity. Since GLP-1 plays a key role in the homeostatic balance of energy metabolism in the postprandial, not restricted to insulin/glucagon secretion.

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