T3enhances Ang2 in rat aorta in myocardial I/R: comparison with left ventricle

What is it about?

The angiopoietins 1/2 and tyrosine kinase receptor represent an essential system in angiogenesis controlling endothelial cell survival and vascular maturation. Recently, in a 3-day ischemia/reperfusion rat model, the infusion of a physiological dose of tri-iodothyronine (T3) was shown to improve the post ischemic recovery of cardiac function. In this work T3 infusion induced a different response of angiopoietin 1/2 between the ventricle (the area at risk and the remote zone) and the thoracic aorta, probably reflecting the different action of angiopoietin 1/2 in cardiomyocytes and endothelial cells.

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Why is it important?

This paper suggests a new aspect of thyroid hormon-mediated cardioprotection through angiogenesis. In fact T3-Ang1/2 function may act in concert with the effects on the cardio-vasculature in order to protect the heart and the peripheral tissues in adverse conditions.

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