What is it about?
Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3'-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and translational rate of mRNAs
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Why is it important?
to better understand the complexities underlying gene expression regulation.
Perspectives
this review summarizes the current state of what we know about RNa binding proteins and their roles in APA
Dr. A. ELIF ERSON-BENSAN
Orta Dogu Teknik Universitesi
Read the Original
This page is a summary of: Alternative polyadenylation and RNA-binding proteins, Journal of Molecular Endocrinology, May 2016, Bioscientifica,
DOI: 10.1530/jme-16-0070.
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