What is it about?
Clinical outcomes (premature death and main cause of death) in persons having both diabetes mellitus and Addison's disease.
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Why is it important?
This nationwide, matched, observational cohort study shows that persons with diabetes mellitus and Addison’s disease compared to controls with only diabetes mellitus have a substantially increased risk of death, mainly due to cardiovascular diseases. Furthermore, persons with diabetes mellitus and Addison’s disease showed an increased death rate from diabetes complications, infectious diseases, and unknown causes compared with controls. When persons with diabetes mellitus were diagnosed with Addison’s disease, the frequency of medical history of cancer and cardiovascular diseases did not differ, but the frequency of diabetes complications was increased compared with their matched control subjects with diabetes mellitus.
Perspectives
Persons with diabetes mellitus have an increased risk of death. The markedly increased mortality in persons with diabetes mellitus after they also suffer from Addison’s disease suggests a direct impact of Addison’s disease and its treatment on mortality. The study supports the fact that having both diabetes mellitus and Addison’s disease is a complex metabolic disorder that needs focused attention with improved management as well as identification and prevention of the co-morbidities that lead to premature death.
Dimitrios Chantzichristos
Vastra Gotalandsregion
Read the Original
This page is a summary of: Mortality in patients with diabetes mellitus and Addison’s disease: a nationwide, matched, observational cohort study, European Journal of Endocrinology, November 2016, Bioscientifica,
DOI: 10.1530/eje-16-0657.
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