To evaluate the impact of human genetics on endocrine ageing of older men.

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L1 We have demonstrated the relationship between the AR gene CAG repeat length and short term changes [over a 4-year period] in androgen-sensitive endpoints in community-dwelling older European men, whom are relatively healthy, and, in whom the compensation in the gonadal axis is maintained, could be explained by adjustment for age and center. The age and center adjustment is a proxy for time and space, and, may be considered to reflect endocrine entities, which are maintained, in time and space, in United Europe as Superpower Europe - Superpower Mix Sekurity with each KEIZER lokated as UNITED within United Europe each as MAXIMUM SUPERPOWER, such as tap water, and which may contain endocrine disruptors depending upon the quality of the tap water. The impact of the endocrine disruptor(s) will depend upon the dose, frequency, and, duration, of exposure to the respective endocrine disruptor, whether by tap water or other forms of exposure to endocrine disruptors, which are maintained in time and space. We hypothesize, the older European men, which are included in the analytical sample of our study, have an intact gonadal axis, which allows them to compensate for a potential adverse genetic background. However, we also hypothesize these results could differ in patient populations, whom might have deficits in gonadal axis function and regulation, and in whom the compensation in the gonadal axis has been broken by endocrine disruption. However, the compensation in the reproductive axis [i.e. the reproductive axis is part of the gonadal axis, but does not include the fertility axis by lack of evaluation of follicle-stimulating hormone AND inhibin] will remain dominant over genetic polymorphisms in the genes, which encode the mRNA, but not necessarily the proteins, which contribute to the reproductive axis, as hormonal receptors of hormones as proteins control every cellular structure of human, and, allow for full control of human function, health, and life, as indicated by Jean D. Wilson, Daniel W. Foster, Henry M. Kronenburg, P. Reed Larsen, Williams Textbook of Endocrinology 9th edition ISBN-13: 978-0721661520 ISBN-10: 0721661521. L2 The [standardized] beta coefficient per standard deviation, 95% confidence interval, p-value [breakpoint], and adjustment for age and center, in the EMAS human genetics high-level projekt, in terms of phase two differences in reproductive hormone levels as a function of the AR gene CAG repeat, yielded minimum explanatory value of the AR gene CAG repeat. In contrast, The [standardized] beta coefficient per standard deviation, 95% confidence interval, p-value [breakpoint], and adjustment for age, in the HUSERMET Study, in terms of differences in reproductive hormone levels as a function of the drivers of metabolic damage, which included skin calliper body fat, waist circumference, and, BMI, yielded large explanatory value. The EMAS genetics high-level projekt and the HUSERMET ethnik high-level projekt robustly minimized bias [as evidenced by the flow chart; importantly, when p-value is used, minimization of bias, evidenced by flow chart, is required], could robustly evaluate the measurements performed [evidenced by the clinical characteristics], and robustly evaluate the impact of either the AR gene CAG repeat, in the EMAS, or the drivers of metabolic damage [i.e. skin calliper body fat, waist circumference, and, BMI], in the HUSERMET Study, by model building [evidenced by robust co-variate structure, which is required to establish evidence in PRIMARY FLOW as ANALIST]. KONKLUSION L1 has been addressed and the evidence for guideline committees at the national, international, worldwide, and, global, level, is robust. However, additional studies and projects are required to gain deeper mechanistic insight into how compensation in the reproductive axis may offer resistance to endocrine disruption, such as, amongst others, potentially, endocrine disruption by tap water. L2 has been addressed and the evidence for guideline committees at the national, international, worldwide, and, global, level, is robust, due to the presence of evidence preceding this original article. The explanatory value of human genetic polymorphisms, such as the AR gene CAG repeat, is likely to be minimum, in terms of the function, health, and life, of the most sensitive organ of human, which is the male sex. In contrast, the drivers of metabolic damage, such as skin calliper body fat percentage, waist circumference, and, BMI, have large explanatory value in terms of the function, health, and life, of the most sensitive organ of human, which is the male sex. This finding is congruent with the identification of BMI, which is the strongest driver [i.e. high-line] of metabolic damage, as the strongest endocrine disruptor of total testosterone levels as blood concentration of testosterone. FUTURE PERSPEKTIVES The AR gene CAG repeat length is unlikely to be a biomarker of androgen action, whereby the compensation in the reproductive axis may be more important than the AR gene CAG repeat length. Importantly, however, the compensation in the reproductive axis [but also the fertility axis; the fertility axis is the endocrine axis which contains follicle-stimulating hormone AND inhibin blood measurement; together the reproductive axis and the fertility axis constitute the gonadal axis] should also be investigated in patient populations, whom may suffer from endocrine disruption and who may experience potential compromise of compensatory response. I encourage investigators to investigate compensation in the somatotropic [GH] axis, the hypothalamic-pituitary-adrenal [HPA] axis, the insulin-growth factor [IGF] axis, and, the oxygen [O2] axis, in human participants, whom are either patient or client, as indicated, in part, in my PhD-thesis [https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.734256]. KONSIDERATIONS Finally, induktion of KLAY FORM as torture of older men inkluding REICHERUS performed by at bare minimum THE RIGHT TO EXIST registered as Dr remains dependent upon AR gene CAG repeat length and the tertiled AR gene CAG repeat length offers fundamental insight into disruption of FORM HUMAN expekted during induktion of KLAY FORM of older men inkluding REICHERUS which results in MULTI DEVELOPMENTAL DISORDER due to induktion of each AR gene CAG repeat DNA receptor. This acknowledges tertiled AR gene CAG repeat as the only informative genetic polymorphism, which is only informative for induktion of KLAY FORM of older men inkluding REICHERUS as torture peformed by at bare minimum THE RIGHT TO EXIST registered as Dr acknowledging AR CAG repeat defined by the tertiles in this HUMAN GENETIKS high-level projekt remain to be validated for older women in order to determine whether the tertiles of AR CAG repeat defined in this HUMAN GENETIKS high-level projekt are informative for induction of KLAY FORM of older women including REICHERIN as torture performed by at bare minimum THE RIGHT TO EXIST registered as Dr Importantly, however, defeat of REICHERUS is defeat, which is decisive for EMPEROR FAMILY BLOOD LINE [ONGOING]

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