Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method

  • Rudolf Hoermann, Rolf Larisch, Johannes W Dietrich, John E M Midgley
  • Acta Endocrinologica, March 2016, Bioscientifica
  • DOI: 10.1530/eje-16-0031

Reference range for TSH

What is it about?

The reference range for TSH is highly impacted by the statistical method used.

Why is it important?

Multivariate reference methods that jointly consider TSH and free thyroid hormones are more appropriate because TSH is an indirect control parameter and the parameters are interlinked.


Professor Rudolf Hoermann

The appropriate reference range for TSH has been a matter of longstanding debate. A multivariate reference range is phyiollogically more appropriate and adds a fundamental perspective to this debate.

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The following have contributed to this page: PD Dr. med. Johannes W Dietrich and Professor Rudolf Hoermann