What is it about?
The reference range for TSH is highly impacted by the statistical method used.
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Why is it important?
Multivariate reference methods that jointly consider TSH and free thyroid hormones are more appropriate because TSH is an indirect control parameter and the parameters are interlinked.
Perspectives
The appropriate reference range for TSH has been a matter of longstanding debate. A multivariate reference range is phyiollogically more appropriate and adds a fundamental perspective to this debate.
Professor Rudolf Hoermann
Read the Original
This page is a summary of: Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method, European Journal of Endocrinology, March 2016, Bioscientifica,
DOI: 10.1530/eje-16-0031.
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