What is it about?
We showed that is possible prolonged clinical remission of type 1 diabetes mellitus with treatment using sitagliptin plus vitamin D3. A patient is without insulin for 5 years.
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Why is it important?
Prolonged clinical remission of type 1 diabetes with sitagliptin and vitamin D3 showed be cheap and safe, and maybe can be use for new-onset type 1 diabetes in teenager and adults.
Perspectives
I believe the association between sitagliptin and vitamin D3 could have benefits as an immunomodulatory drug in type 1 diabetes mellitus, because they act synergistically over the immune system, adding regulatory effect on Treg cells and Th17 cells, normalizing the imbalance between these cells. Furthermore, the incretin effects of the sitagliptin, which increases the GLP-1 levels, could protect the beta cells. Sitagliptin and vitamin D3 could also regulate a wide variety of inflammatory cytokynes.
MD,PhD MARCELO MAIA PINHEIRO
Univag - University Center
Read the Original
This page is a summary of: Four-year clinical remission of type 1 diabetes mellitus in two patients treated with sitagliptin and vitamin D3, Endocrinology Diabetes and Metabolism Case Reports, December 2016, Bioscientifica,
DOI: 10.1530/edm-16-0099.
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